Research Information System
Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.39, no.2, pp.113-122, 2010 (Scopus)
Species of genus Salvia (Sage) are well known herbs in traditional medicine. Antimicrobial and antioxidant effects of aerial parts of sage are studied in detail. However, there has been no record for Salvia albimaculata Hedge & Hub. This study was performed to assess any possible antinociceptive effect of S. albimaculata. Since S. albimaculata is an endemic of Turkey this study constitutes the first pharmacological investigation of this species. Aqueous, ethanolic and ethyl acetate extracts of S. albimaculata were prepared at room temperature with maceration. Extracts were given at doses of 100 and 200 mg/kg to mice. Hotplate and acetic acid induced writhing tests were performed to animals after 30 minutes of oral application. S. albimaculata ethanolic extract in 100 and 200 mg/kg dose showed a significant antinociceptive effect in acetic acid induced writhing test. However, in any of the doses applied, S. albimaculata extract didn't change the hind-leg retraction period in hotplate test. Therefore it is possible to conclude that S. albimaculata has a perypheral antinociceptive effect on mice evaluated from chemical pain model. However it has no central antinociceptive activity according to thermal pain model. Further research on this species including bioactivity guided fractionation will reveal the main ingredients responsible from this antinociceptive activity.