Optimization of process parameters and kinetic modeling for the enantioselective kinetic resolution of (R, S)-2-pentanol

Malyemez A. S., BAYRAKTAR E., Mehmetoglu U.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.6, pp.600-608, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1515/tjb-2016-0299
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.600-608
  • Keywords: Racemic-2-pentanol, Kinetic resolution, Trans-esterification, Kinetic model, Enantiomeric excess, SECONDARY ALCOHOLS, CANDIDA-ANTARCTICA, LIPASE-B, TRANSESTERIFICATION, RAC-2-PENTANOL, SOLVENT
  • Ankara University Affiliated: Yes

Abstract

Introduction: In order to product (S)-2-pentanol which have been used as a key chiral intermediate required in the synthesis of several potential anti-Alzhemeir drugs, the effects of enzyme, acyl donor, substrate concentration and acyl donor/racemic-2-pentanol mole ratio were investigated on the kinetic resolution of racemic-2-pentanol.