Can omentin-1 be a prognostic marker in surgical intensive care patients?

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Gultekin Y., Biri I., Gojayev A., YILMAZ IŞIKHAN S., PORTAKAL AKÇİN O., KILIÇ Y. A.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.51, no.5, pp.2485-2493, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2009-158
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.2485-2493
  • Keywords: Intensive care, omentin, prognostic marker, SERUM OMENTIN-1, ADIPOSE-TISSUE, INFLAMMATION, SEPSIS, ADIPONECTIN, ADIPOKINES, EXPRESSION, OBESITY
  • Ankara University Affiliated: Yes

Abstract

Background/aim: A member of the adipokine family, omentin-1 is selectively secreted from visceral fat tissue and the omentum. It has been shown that omentin-1 is involved in the pathogenesis of certain diseases and can be used as a prognostic marker. This study first investigated the prognostic significance of omentin-1 in surgical intensive care patients. In addition, the relationship between omentin-1 and laboratory and clinical parameters commonly used in intensive care units (ICUs) was evaluated. Materials and methods: One hundred and fifty-four patients hospitalized in the surgical ICU were included in the study. Blood samples for omentin-1 were collected from the patients displaying clinical condition changes. Changes in omentin-1 levels were observed during the hospital stay of the patients. A total of 423 blood samples were evaluated. Omentin-1 levels were compared to the laboratory parameters routinely monitored in the ICU and the prognostic significance of omentin-1 for surgical intensive care patients was investigated. Results: The median APACHE II score of all patients was (median-IQR, 8.0-6.0 ng/mL). Omentin-1 levels of the alive patients in the ICU (median-IQR, 339.04-407.68 ng/mL) were significantly higher compared to dead patients (median-IQR, 166.40-363.60 ng/ mL). Omentin-1 levels were higher in nonsepsis patients compared to the levels of the patients in sepsis and septic shock (p < 0.001). Omentin-1 values were negatively correlated with the C-reactive protein and procalcitonin levels, body temperature, and the SOFA (sequential organ failure assessment score) scores and they were positively correlated with albumin, prealbumin, and glucose levels. Conclusion: Omentin-1 may play a role in the complex constructs of inflammation and metabolic events in intensive care patients. Reduced omentin-1 levels in surgical intensive care patients were associated with poor prognosis and increased mortality.